Medico-Legal Aspects of Antidotes: Legislation, Drug Stockpiles and Proposals

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Article Type: Short Communication
Issue: Vol. 1 No. 1 (2025)
Published: 08 November 2025
Pages: 59-69

How to Cite

Salducci, M., & Raimondi, R. (2025). Medico-Legal Aspects of Antidotes: Legislation, Drug Stockpiles and Proposals. Crisis and Resilience, 1(1), 59-69. https://doi.org/10.65773/cr.1.1.37

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Authors

Mauro Salducci 1 , 
Raimondo Raimondi 2 *
1 Sapienza Department of Sense Organs, Sapienza University of Rome , Rome, Italy
2 Military Corps vol. CRI , Forensic Medical Department , Rome, Italy

Abstract

The medico-legal aspects relating to antidotes concern their availability, efficacy and correct management in case of intoxication, both accidental and intentional. Forensic medicine, in this context, assesses whether the use of antidotes was appropriate and whether there are responsibilities related to their non-availability or improper use.

Keywords:
Antidotes Forensics Drug Stock

Article Details

References

[1]World Health Organization. (2020). Guidelines for establishing a poison centre. https://www.who.int/publications/i/item/9789240009523.

[2]Smollin, C. G. (2010). Toxicology: Pearls and pitfalls in the use of antidotes. Emergency Medicine Clinics of North America, 28(1), 149–161. https://doi.org/10.1016/j.emc.2009.09.009

[3]Pronczuk de Garbino, J., Haines, J. A., Jacobsen, D., & Meredith, T. (1997). Evaluation of antidotes: Activities of the International Programme on Chemical Safety. Journal of Toxicology: Clinical Toxicology, 35(4), 333–343. https://doi.org/10.3109/15563659709043364

[4]Yin, H., Zhang, X., Wei, J., Lu, S., Bardelang, D., & Wang, R. (2021). Recent advances in supramolecular antidotes. Theranostics, 11(3), 1513–1526. https://doi.org/10.7150/thno.53459

[5]Anez-Bustillos, L., Dao, D. T., Baker, M. A., Fell, G. L., Puder, M., & Gura, K. M. (2016). Intravenous fat emulsion formulations for the adult and pediatric patient: Understanding the differences. Nutrition in Clinical Practice, 31(5), 596–609. https://doi.org/10.1177/0884533616662996

[6]Pohanka, M. (2019). Antidotes against methanol poisoning: A review. Mini-Reviews in Medicinal Chemistry, 19(14), 1126–1133. https://doi.org/10.2174/1389557519666190312150407

[7]Botelho, F. D., Franca, T. C. C., & LaPlante, S. R. (2024). The search for antidotes against ricin. Mini-Reviews in Medicinal Chemistry, 24(12), 1148–1161. https://doi.org/10.2174/0113895575270509231121060105

[8]Forster, V., & Leroux, J.-C. (2015). Nano-antidotes for drug overdose and poisoning. Science Translational Medicine, 7(290), 290ps14. https://doi.org/10.1126/scitranslmed.3008736

[9]Godier, A., & Martin, A.-C. (2019). Specific antidotes for direct oral anticoagulant reversal: Case closed or cold case? Circulation, 140(18), 1445–1447. https://doi.org/10.1161/CIRCULATIONAHA.119.041687

[10]Buckley, N. A., Dawson, A. H., Juurlink, D. N., & Isbister, G. K. (2016). Who gets antidotes? Choosing the chosen few. British Journal of Clinical Pharmacology, 81(3), 402–407. https://doi.org/10.1111/bcp.12894

[11]De Felice, F., Pranno, N., Marampon, F., Musio, D., Salducci, M., Polimeni, A., & Tombolini, V. (2019). Immune check-point in glioblastoma multiforme. Critical Reviews in Oncology/Hematology, 138, 60–69. https://doi.org/10.1016/j.critrevonc.2019.03.019

[12]Shahbaz, R., & Salducci, M. (2021). Law and order of modern ophthalmology: Teleophthalmology, smartphones legal and ethics. European Journal of Ophthalmology, 31(1), 13–21. https://doi.org/10.1177/1120672120934405.

[13]Firmani, G., Salducci, M., Testa, F., Covelli, G. P., Sagnelli, P., & Lambiase, A. (2024). Ocular biomarkers in Alzheimer's disease: Insights into early detection through eye-based diagnostics—A literature review. La Clinica Terapeutica, 175(5), 352–361. https://doi.org/10.7417/CT.2024.5125

[14]Messineo, D., Massaro, F., Izzo, P., Milani, A., Polimeni, R., Iannella, G., Marinozzi, S., Consorti, F., Cocuzza, S., Maniaci, A., Mucchino, A., Nannarelli, M., Greco, A., Magliulo, G., Salducci, M., & Pace, A. (2024). Radiomic application for head and neck squamocellular tumor: Systematic review. La Clinica Terapeutica, 175(2), 153–160. https://doi.org/10.7417/CT.2024.5048

[15] Salducci, M., & Shaholli, D. (2024). Historical evolution of the passenger ship's doctor. The Medico-Legal Journal, 92(2), 96–98. https://doi.org/10.1177/00258172231223046

[16] Salducci, M., Raimondi, R., & Simonelli, M. S. (2025). Medico legal study on the correct management of the medical clinic in the military field. La Clinica Terapeutica, 176(4), 512–514. https://doi.org/10.7417/CT.2025.5256

[17]Salducci, M., Martines, V., & Simonelli, M. S. (2025). Medical legal evaluations on the radiological error: Has the use of PACS introduced changes in cognitive errors? La Clinica Terapeutica, 176(3), 391–393. https://doi.org/10.7417/CT.2025.5239

[18]Palumbo, V., Maricchiolo, G., Morano, V., Salducci, M., Stigliano, S., Palermo, A., Di Matteo, F. M., Crescenzi, A., Taffon, C., Naciu, A. M., & Bonfiglio, R. (2024). From sampling to cellblock: The fully automated journey of cytological specimens. Diagnostic Cytopathology, 52(11), 611–616. https://doi.org/10.1002/dc.25366

[19]Salducci, M., & La Torre, G. (2020). COVID-19 emergency in the cruise’s ship: A case report of conjunctivitis. La Clinica Terapeutica, 171(3), e189–e191. https://doi.org/10.7417/CT.2020.2212

[20]Bodini, S., Pieralice, S., D’Onofrio, L., Mignogna, C., Coraggio, L., Amendolara, R., Risi, R., Salducci, M., Buzzetti, R., & Maddaloni, E. (2024). No differences in kidney function decline between people with type 2 diabetes starting a sodium-glucose cotransporter 2 inhibitor or a glucagon-like peptide-1 receptor agonist: A real-world retrospective comparative observational study. Clinical Therapeutics, 46(11), 828–834. https://doi.org/10.1016/j.clinthera.2024.04.009

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